Dynamic Expression of Neurotrophin Receptors during Sensory Neuron Genesis and Differentiation
نویسندگان
چکیده
منابع مشابه
Lamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation
B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in developmental contexts, a direct link between B-type lamins and developmental gene expression in an in vivo system is currently lacking. Here, we identify lamin B1 as a key regulator of gen...
متن کاملDynamic regulation of the expression of neurotrophin receptors by Runx3.
Sensory neurons in the dorsal root ganglion (DRG) specifically project axons to central and peripheral targets according to their sensory modality. However, the molecular mechanisms that govern sensory neuron differentiation and the axonal projections remain unclear. The Runt-related transcription factors, Runx1 and Runx3, are expressed in DRG neuronal subpopulations, suggesting that they might...
متن کاملDifferential expression of neurotrophin receptors during renal development.
Early kidney differentiation is driven by local cell-cell interactions. The metanephrogenic mesenchyme stimulates the epithelial ureter bud to grow and branch, whereas the ureter bud stimulates the mesenchyme to convert into a new epithelium. These interactions may be dependent on local growth factors and their receptors. We studied the expression of receptors for nerve growth factors during ki...
متن کاملExpression pattern of neurotrophins and their receptors during neuronal differentiation of adipose-derived stem cells in simulated microgravity condition
Objective(s): Studies have confirmed that microgravity, as a mechanical factor, influences both differentiation and function of mesenchymal stem cells. Here we investigated the effects of simulated microgravity on neural differentiation of human adipose-derived stem cells (ADSCs). Materials and Methods:We have used a fast rotating clinostat (clinorotation) to simulate microgravity condition. R...
متن کاملExpression of Trk receptors during cartilage differentiation.
The products of the tyrosine kinase trk family of proto-oncogenes bind neurotrophins (NTFs) and are components of their high-affinity receptors. The trk gene encodes for the TrkA transmembrane glycoprotein, which functions as a receptor for nerve growth factor (NGF). Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) are the preferred ligands for TrkB. and neurotrophin-3 (NT-3) ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2000
ISSN: 0012-1606
DOI: 10.1006/dbio.2000.9841